A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology.

The preventive effect of a nasally administered single dose of the dipeptide N-acetyl-aspartyl-glutamate (NAAGA) on pollen-induced early nasal reaction as measured by rhinomanometry and symptomatology was investigated in a double-blind cross-over placebo controlled study in 18 patients with nasal sensitization to grass pollen. Mean nasal airways resistance at 20, 40, and 60 min post challenge was, respectively, 33%, 37% (P = 0.03) and 27% less after NAAGA than after placebo administration in the same patients. In contrast, no significant effect on sneeze count and rhinorrhoea was found.