Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2019
This study will evaluate the efficacy and safety of pembrolizumab (MK‐3475) with lenvatinib (E7080/MK‐7902) vs. docetaxel in participants with metastatic non‐small cell lung cancer (NSCLC) and progressive disease (PD) after platinum doublet chemotherapy and treatment with one prior anti‐PD‐1/PD‐L1 monoclonal antibody (mAb). The primary hypotheses of this study are that pembrolizumab + lenvatinib (compared with docetaxel) prolongs: 1) overall survival (OS); and progression‐free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) based on blinded independent central review (BICR).
Epistemonikos ID: 2bee34192449e12c174d1374eaaf5d85a563b47c
First added on: May 22, 2024