Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers

This randomized controlled trial aims to evaluate the non‐inferiority of Mindful Awareness Practices for Insomnia (MAP‐I ) vs. Cognitive Behavioral Therapy for Insomnia (CBT‐I) on outcomes of insomnia, cellular and genomic markers of inflammation, and cellular aging in older adult AD spousal caregivers with insomnia (N=150) over one‐year follow‐up. The specific aims of this project are: Primary Aim 1: Determine the effects of MAP‐I vs. CBT‐I on subjective and objective dimensions of insomnia. Secondary Aim 1: Evaluate the effects of MAP‐I vs. CBT‐I on cellular and genomic markers of inflammation. Secondary Aim 2: Evaluate the effects of MAP‐I vs. CBT‐I on markers of cellular aging. Exploratory Aim 1: Explore moderating effects of caregiver stress (Stress and Adversity Inventory, STRAIN, number & experienced intensity of stress exposure) on insomnia outcomes, and effects of MAP‐I vs. CBT‐I on caregiver stress, health functioning, chronic medical morbidity and related medication use at follow‐up.