oral collagen supplement and i-ipf in patient with temporomandibular joint disorder along with arthrocentesis procedure

INTERVENTION: Intervention1: oral nutraceutical supplement: ( collagen + sodium hyaluronate + curcumin + Boswellia + Piperine ) Control Intervention1: PLACEBO GROUP: PLACEBO GROUP ( TAB PLACEBO BD X2 months ) CONDITION: Health Condition 1: K089‐ Disorder of teeth and supporting structures, unspecified Health Condition 2: K088‐ Other specified disorders of teethand supporting structures PRIMARY OUTCOME: To evaluate and compare the analgesic efficacy oral nutraceutical (Collagen + sodium hyaluronate + ; Curcurmin + Boswellia + piperine) as adjunct to arthrocentesis‐ iPRF in management of patients with ; Temporomandibular joint derangement .Timepoint: DAY 0 ; 7 DAY ; 14 DAY ; 1 MONTH ; 3 MONTHS ; 6 MONTHS SECONDARY OUTCOME: 1. To evaluate & compare the effect on jaw function (mouth opening, lateral movement, protrusive ; movements) of Temporomandibular joint derangement patients in oral nutraceutical ( collagen + ; sodium hyaluronate + curcumin + Boswellia + Piperine ) along with arthrocentesis and‐ iPRF versus ; arthrocentesis ‐ iPRF alone . ; 2. To evaluate & compare the radiologic changes (MRI) in patients of Temporomandibular joint ; derangement treated with oral nutraceutical supplement ( collagen + sodium hyaluronate + curcumin ; + Boswellia + Piperine ) along with arthrocentesis & I‐PRF versus arthrocentesis & I‐PRF alone. ; 3. To evaluate & compare the quality of life in Temporomandibular joint derangement patients treated ; with oral nutraceutical supplement ( collagen + sodium hyaluronate + curcumin + Boswellia + ; Piperine ) along with arthrocentesis & iPRF versus arthrocentesis & iPRF alone .Timepoint: DAY 0 ; 7 DAY ; 14 DAY ; 1 MONTH ; 3 MONTHS ; 6 MONTHS INCLUSION CRITERIA: 1. Patients who have given written informed consent to be a part of the study. 2. Adult patients of either se XAge 18‐60 years 3. ASA I or ll 4.Patients with Wilkes classification of Internal Derangement stage III and stage IV only with positive Mahan test