Effects of Plant Sterol Intervention on Borderline Dyslipidemia and Its Mechanisms Based on Cholesterol Metabolism–Related Genetic Background and Gut Microbiota Regulationhao

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Intervention group(RCT):Participants in the intervention group consumed one bottle (250 mL) of soy milk supplemented with plant sterols each day, with each bottle containing 2.0 g of plant sterols.;RCT Control group(RCT):Participants in the control group consumed one bottle (250 mL) of regular soy milk each day.;Case group (case‐control study):No;Control group (case‐control study):No; CONDITION: Hyperlipidemia PRIMARY OUTCOME: Total Cholesterol ;Triglyceride ;Low‐density lipoprotein cholesterol;High‐density lipoprotein cholesterol; SECONDARY OUTCOME: Creatinine;Gut microbiota diversity;Cholic acid;Glycocholic acid;Taurocholic acid;Taurolithocholic acid;Glycolithocholic acid;Deoxycholic acid;Chenodeoxycholic acid;Ursodeoxycholic acid;Campesterol;Avenastero;ß‐Sitosterol;Stigmasterol;Squalene;24‐dehydrocholesterol;7‐Elestachol;Food frequency questionaire; INCLUSION CRITERIA: Inclusion criteria for case‐control studies: 1. Agreement to participate in the study and signing of the informed consent form (case group); 2. Age of at least 18 years (case group); 3. Diagnostic criteria for cases: TC >= 5.2 mmol/L, TG >= 1.7 mmol/L, LDL‐C >= 3.4 mmol/L, HDL‐C < 1.0 mmol/L (case group). 4. Healthy individuals who have undergone a physical examination (control group). Inclusion criteria for RCT studies: 1. Agreement to participate in the study and signing of the informed consent form; 2. Age between 30 and 65 years; 3. Patients who were diagnosed for the first time as having borderline elevated lipid levels according to the "Guidelines for the Prevention and Treatment of Lipid Disorders in Chinese Adults (2016 revised edition)" and who have signed the informed consent form. Diagnostic criteria for such patients: fasting TC levels of 5.2 <= TC < 6.2 mmol/L and/or TG levels of 1.7 <= TG < 2.3 mmol/L and/or LDL‐C le
Epistemonikos ID: 28b282c05f6d6ab6318662f8db0c97565460ed88
First added on: Oct 08, 2026