Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase.

Authors
Category Primary study
JournalBioorganic & medicinal chemistry letters
Year 2001
Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.
Epistemonikos ID: 289bb344c1289578f9eeebe2a2d24d643c115d6b
First added on: Dec 08, 2021