Randomized, Double-Blind, Placebo-Controlled Trial Protocol of AI-Optimized Formula Granules for Preventing Postoperative Recurrence of Colorectal Adenoma

Authors
Category Primary study
Registry of TrialsInternational Traditional Medicine Clinical Trial Registry
Year 2026
INTERVENTION: Experimental group:Oral Chinese herbal granules;control group:Oral placebo; CONDITION: Colorectal adenoma DB35 PRIMARY OUTCOME: Adenoma recurrence rate; SECONDARY OUTCOME: Gastrointestinal Symptom Scale Score;Anxiety;Depression;Number and nature of intestinal polyps; INCLUSION CRITERIA: Patients must meet all 6 of the following criteria to be eligible for this study: 1) Aged 18–75 years; gender is not restricted. 2) Patients diagnosed via colonoscopy within the past 6 months and who have undergone complete endoscopic resection of pathologically confirmed advanced colorectal adenomas (including villous adenomas, tubular‐villous adenomas, and tubular adenomas). Patients must have histologically confirmed presence of 1–6 colorectal adenomas. 3) With or without symptoms such as constipation, diarrhea, or abdominal distension. 4) Boston Bowel Preparation Score = 6. 5) Familial adenomatous polyposis or polyposis has been ruled out based on medical and family history. 6) Willing to participate and has signed an informed consent form.
Epistemonikos ID: 27e5bb349b4497d60bbd5354bb0ffe5decfcc158
First added on: Jul 25, 2026