Phytochemical and clinical effect of a herbal medicine containing mint, rosemary, lavender, and clove compared to placebo on the prevention and control of migraine symptoms

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2026
INTERVENTION: Intervention 1: Intervention group 1: Routine treatment plus herbal medicine containing mint applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one month. Intervention 2: Intervention group 2: Routine treatment plus herbal medicine containing rosemary applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one month. Intervention 3: Intervention group 3: Routine treatment plus herbal medicine containing lavender applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one month. Intervention 4: Intervention group 4: Routine treatment plus combined herbal medicine containing clove applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one month. Intervention 5: Control group: Routine treatment plus placebo without any herbal ingredient applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one month. CONDITION: Migraine. ; Migraine PRIMARY OUTCOME: Headache severity. Timepoint: Before intervention and one month later. Method of measurement: Using the Visual Analogue Scale (VAS). Mean duration of migraine attacks. Timepoint: Before intervention and one month later. Method of measurement: By medical history. Number of migraine attacks. Timepoint: Before intervention and one month later. Method of measurement: By medical history. SECONDARY OUTCOME: Amount of analgesic medication use. Timepoint: before intervention and one month later. Method of measurement: By medical history. Improvement in sleep quality. Timepoint: Before intervention and one month later. Method of measurement: Using the Pittsburgh Sleep Quality Inde X(PSQI). Mean mood and anxiety score. Timepoint: before intervention and one month later. Method of measurement: Using the Depression Anxiety Stress Scales ‐ 21 (DASS‐21). Mean patient satisfaction score. Timepoint: Before intervention and one month later. Method of measurement: Using a researcher‐designed questionnaire. INCLUSION CRITERIA: Age 18 to 55 years, Diagnosis of migraine, Experience of at least 4 migraine attacks in the past three months,
Epistemonikos ID: 262ba44436613ea6422a2be00bc8dbd58e5095d6
First added on: Aug 08, 2026