To explore the mechanism of Meridian-Sinew Release Therapy in RA based on the JAK-STAT pathway

INTERVENTION: control group:Drug treatment combined with acupuncture treatment;Treatment group:Drug treatment combined meridian‐Sinew Release therapy; CONDITION: rheumatoid arthritis PRIMARY OUTCOME: Erythrocyte sedimentation rate;C‐reactive protein;Inflammatory cytokines;rheumatoid factor;JAK‐STAT signaling protein JAK1, STAT3 expression and phosphorylation levels;cytokine signal transduction inhibitor factor SOCS1;inflammatory factor TNF‐a;inflammatory factor IL‐6; INCLUSION CRITERIA: 1. Patients who meet the classification criteria of rheumatoid arthritis jointly formulated by ACR / EULAR in 2010; 2. Aged between 18 and 75; 3. The disease is in the activity period (DAS > 2.6); 4. The patient has at least one knee joint involved; 5. Subjects give informed consent and sign the consent form.