A multicenter, randomized, controlled trial comparing the efficacy of oral fluoroquinolone and aminopenicillin with intravenous Cephalosporin in low-risk pediatric cancer patients with febrile neutropenia

INTERVENTION: Tosufloxacin + Amoxicillin/clavulanate (oral) Cefepime (intravenous) CONDITION: Childhood cancer PRIMARY OUTCOME: Treatment success rate defined as resolution rate of febrile neutropenia without change of treatment regimen SECONDARY OUTCOME: Duration of fever, Positive rates of blood cultures, Rates of adverse events, Rates of recurrence of fever INCLUSION CRITERIA: 1)Patients diagnosed as pediatric cancer with age 1 to 19 years 2)Febrile (1 episode of axillary temperature above 38.3 degrees or 2 episodes of 38 degrees taken on two occasions at least 1 hour apart within the last 24 hours ) 3) Absolute neutrophil count (ANC) less than 1000/microliter (band cell + segmented cell) in peripheral blood sample within 3 days including the day of developing fever 4)Informed consent is taken by substitute and the patient over 16 years old in writing