Preservative-free Tafluprost/Timolol Fixed Combination: morning vs Evening Dosing

Prospective, observer‐masked, placebo‐controlled, crossover, comparison in consecutive open‐angle glaucoma patients, insufficiently controlled with preserved latanoprost monotherapy (mean 24‐hr IOP greater than 20 mmHg). Patients were randomized to either morning (08:00), or evening (20:00) preservative‐free tafluprost/timolol fixed combination for 3 months and then were crossed over. After each treatment period patients underwent habitual 24‐hour intraocular pressure monitoring with Goldmann tonometry in the sitting position (at 10:00, 14:00, 18:00 and 22:00) and Perkins tonometry in the supine position (at 02:00 and 06:00). Primary Study Objective: Mean 24‐hour efficacy with both dosing regimens of tafluprost/timolol fixed combination versus latanoprost monotherapy. Secondary Study Objectives 1. Mean efficacy with the evening dosing of tafluprost/timolol compared with the morning‐dosed tafluprost/timolol fixed combination at each time point measured. 2. Mean daytime and mean nighttime IOP control with the two dosing regimens. 3. Mean peak and fluctuation of 24‐hour pressure with the evening and the morning dosing of the fixed combination.