A pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time lapse imaging in in-vitro fertilisation treatment

INTERVENTION: Group 1:incubation and assessment of embryos using TLI systems;Group 2:incubation of embryos in undisturbed culture and standard embryo assessment;Control group:Standard care; CONDITION: infertility PRIMARY OUTCOME: Live birth; SECONDARY OUTCOME: Clinical efficacy;Clinical safety; INCLUSION CRITERIA: The inclusion criteria are broad in keeping with the latest NICE guidelines (2013) for NHS funded IVF/ICSI treatment. Participants undergoing IVF/ICSI treatment and 1) the woman is between 18 and 42 years of age at the time of consent; 2) the male partner is at least 18 years of age at the time of consent; 3) receiving the first, second or third IVF/ICSI treatment cycle; 4) both partners give written informed consent; 5) those having at least 3 2PN embryos (showing 2 pro‐nucleii which is a sign of normal fertilisation) on day of fertilization check.