Ovarian stimulation with follicle stimulating hormone (r-FSH) for women with high early follicular FSH and intra-uterine insemination (IUI) indication

INTERVENTION: Couples will undergo a maximum of 6 IUI cycles. Group 1: Three unstimulated IUI cycles, followed by three stimulated IUI cycles with r‐FSH (follitropine). R‐FSH will be given starting from day 3 of the cycle until one or more follicles reach 18 mm diameter, followed by hCG administration 10,000 IU and insemination. Dose will be increased in the next cycle until multifollicular growth occurs. Group 2: Six stimulated IUI cycles. R‐FSH will be given starting from day 3 of the cycle until one or more follicles reach 18 mm diameter, followed by hCG administration 10,000 IU and insemination. Dose will be increased in the next cycle until multifollicular growth occurs. CONDITION: Subfertility ; Urological and Genital Diseases ; Female infertility PRIMARY OUTCOME: Multifollicular growth (on day of hCG administration, measured with ultrasound). SECONDARY OUTCOME: 1. Pregnancy rate; 2. FSH doses used; 3. Cancellation rate; 4. Side‐effects of medication; 5. Treatment load INCLUSION CRITERIA: 1. Women with elevated early follicular FSH (cycle day 2‐4) 2. Women between 18 and 45 years 3. Regular menstrual cycle between 25 and 35 days 4. Indication for IUI treatment 5. Normal hysterosalpingography 6. Normal serum Ca‐125 7. Semen analyses: >2 million progressive motile spermatozoa 8. Ovulatory cycle