Effects of contralateral electroacupuncture on brain function: A double-blind, randomized, pilot clinical trial

Objectives: The aim of this study was to ascertain the effects of contralateral acupuncture on brain function using blind-spot mapping. Design and participants: Forty (40) healthy volunteers in whom the right-side blind spot was larger than the left-side one-which indicates lower left-brain function-were randomly assigned into the following two groups in which electroacupuncture was applied to: (1) the contralateral ST36 acupuncture point (right side), and (2) the ipsilateral ST36 acupuncture point (left side). Outcome measure: Blind-spot perimetry length was the outcome measure. Results: Electroacupuncture to the contralateral side decreased the blind-spot perimetry length by 5.0 (-9.3 to 0.9) [median (interquartile range, IQR)], whereas that to the ipsilateral side increased the length by 4.5 (-3.7 to 7.8) [median, IQR]. There was significant difference in this length between the two groups (p < 0.05). Conclusions: These results suggest that electroacupuncture application increased or decreased the brain function-as assessed by changes to the blind spot-depending on the treatment side: Contralateral-side, treatment has a better effect than ipsilateral-side treatment on brain function. However, further randomized studies that include both right- and left- side-enlarged subjects with a sham needle are needed to convincingly show the effects of contralateral acupuncture on brain function.