Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
This randomized controlled clinical trial was undertaken to evaluate and compare theeffectiveness of chlorhexidine gluconate gel (1%) alone and a combination gel containingchlorhexidine gluconate (0.5%) with metronidazole (1.5%) as adjuncts to scaling and rootplaning in the management of gingival inflammation over a period of 12 weeks.120 participants were assigned to three groups: scaling and root planing with placebogel, scaling and root planing with 1% chlorhexidine gluconate gel, and scaling and rootplaning with a combination of 0.5% chlorhexidine gluconate and 1.5% metronidazole gel.Clinical periodontal parameters were assessed to compare the effectiveness of theinterventions in reducing plaque accumulation and gingival inflammation.
Epistemonikos ID: 21bea69f409270f2ee6761347a84111973d2896f
First added on: Aug 20, 2026