Anti-acrolein from natural products by regulating miRNAs and targets.

Acrolein is a common environmental and metabolic toxicant, and natural products that counteract its toxicity can benefit human health. This review interprets the effects of 34 miRNAs and 33 targets involved in acrolein toxicity and explores the acrolein-counteracting functions of 31 natural products. Since the natural products, miRNAs, and targets involved in acrolein toxicity have yet to be systematically evaluated, their integrated relationships are examined via the target-target interaction bioinformatics tool STRING using information retrieved from Google Scholar. Moreover, the interplay between these natural products and miRNAs is explored in detail and integrated into the STRING target network, with 169 target-target interactions. Overall, this review presents a novel natural-product-miRNA-target axis against acrolein toxicity. It sheds light on a number of viable research directions for understanding the effects of acrolein toxicity, as well as the molecular mechanisms underlying its alleviation, via a systematic analysis of natural products, miRNAs, and target interactions.