CHAMPION PCI

INTERVENTION: Subjects who fulfill the criteria and are to under go PCI will be randomised on a 1:1 randomisation to receive either 4 placebo capsules orally plus Cangrelor bolus (30ug/kg) & infusion (4 ug/kg/min) for at least 2 hours or the duration of the procedure, whichever is longer. Post infusion be administered 4 Clopidogrel capsules (600mg) orally once. The other group would receive 4 Clopidogrel capsules (600mg) plus Placebo bolus (30 ug/kg) and infusion (4 ug/kg/min) for the duration of the procedure or 2 hours whichever is longer. At the end of the infusion they will receive 4 placebo capsules once. Clopidogrel maintenance is at the physicians discretion. CONDITION: Acute Coronary Syndromes Myocardial Infarction Unstable Angina PRIMARY OUTCOME: All cause mortality Ischaemic driven revascularization Myocardial Infaction SECONDARY OUTCOME: All cause mortality and myocardial infarction INCLUSION CRITERIA: Diagnostic coronary angiography demonstrating atherosclerosis amenable to treatment by PCI with or without stent implantation and one of the following: 1. Non ST segment myocardial infarction with Troponin I or T greater than upper limit of normal within 24 hours of randomisation. 2. Unstable angina with ischaemic chest discomfort occurring at rest and lasting longer than 10 minutes within 24 hours of randomisation and with dynamic ECG changes with age greater than 65 years or diabetes.