Evaluation of Postsurgical Wound Healing, Pain and Complications of Plasma Pen-Assisted Surgery of Reactive Exophytic Oral Soft Tissue Lesions Compared to Conventional Surgery: A Randomized Clinical Trial

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2025
INTERVENTION: Intervention 1: Intervention group: After baseline examination and obtaining an informed consent, the lesions will be completely excised under local anesthesia using ?% lidocaine with ?:??,??? epinephrine using a plasma pen under perfectly aseptic conditions. Excision will be performed according to the standard oral surgical procedures. After retracting the basal part of the lesion superiorly using a clamp, excision will be performed such that the borders were in the intact tissue. It is important to note that the wounds occurred after the excisions with plasma pen will be allowed for secondary healing. Intervention 2: Control group: After baseline examination and obtaining an informed consent, the lesions will be completely excised under local anesthesia using ?% lidocaine with ?:??,??? epinephrine using a surgical blade under perfectly aseptic conditions. Excision will be performed according to the standard oral surgical procedures. After retracting the basal part of the lesion superiorly using a clamp, excision will be performed such that the borders were in the intact tissue.The incision will be closed by suture after bleeding has been controlled. CONDITION: Reactive Exophytic Oral Soft Tissue Lesions. ; Benign neoplasm of mouth and pharynx PRIMARY OUTCOME: Complications. Timepoint: On days 7, 14, 28, and 84 after surgery. Method of measurement: Visual inspection to examine the surgery site for any visible changes such as redness, swelling, discoloration, scar, or recurrence, and palpation to assess for any palpable abnormalities. Pain Level. Timepoint: 24 hours after the surgery, and again after 2, 3, 4, 5, 6, and 7 days. Method of measurement: Visual Analogue Scale. Wound Healing. Timepoint: On days 7, 14, 28, and 84 after surgery. Method of measurement: Wound healing index described by Landry et al, which evaluate parameters such as presence of bleeding, supporation, granulation tissue, tissue color, and epithelialization. INCLUSION CRITERIA: subjects (both males and females) aged ?? years or older Subjects diagnosed with reactive exophytic oral soft tissue lesions (less than one centimeter) on the buccal mucosa based on the clinical findings Subjects who are willing to participate and complete this study
Epistemonikos ID: 210098119ad7b62469702a25d37c015041da7af7
First added on: Sep 08, 2025