A randomized controlled trial of Ruanjian Qingmai Granule in the treatment of peripheral arterial disease

INTERVENTION: control group:placebo;treatment group:Renjian Qingmai granule; CONDITION: peripheral arterial disease PRIMARY OUTCOME: pain free walking distance;max walking distance; SECONDARY OUTCOME: quality of life,MOS SF‐36;TCM syndromes and main symptoms;ABI;the walking impairment questionnaire; INCLUSION CRITERIA: (1) Meet diagnostic criteria of PAD: ? Age > 40 years old, with smoking, diabetes, hypertension, hyperlipidemia and other high‐risk factors, there are clinical manifestations of lower limb ischemia, such as intermittent claudication, affected limb skin temperature drop, numbness, skin hair loss and other affected limb dorsal or posterior tibial artery pulse weakened or disappeared; ?ABI 0.9 or less; ? Color Doppler ultrasound, CTA, MRA or DSA imaging examination showed stenosis or occlusion of the corresponding lower limb arteries; (2) Meet the diagnostic criteria of TCM (syndrome of phlegm‐dampness blocking collaterals): Phlegm and dampness syndrome: sore and swollen, fatigued, swollen; Blood stasis syndrome: main syndrome: ? lower limb pain, dark red skin color or low skin temperature; ? Intermittent claudication; ? The pulsatile of dorsalis pedalis and posterior tibial artery was weakened or disappeared; Secondary syndromes: The skin is dry and de