The influence of metformin and a hypocaloric diet on thyroid radioactive iodide uptake in healthy volunteers: a pilot study

INTERVENTION: group1: 2 week course of metformin and iodide restricted diet Group 2: 2 week course of hypocaloric, iodide restricted diet Groep 3 (control group): 2 week course of iodide restricted diet CONDITION: Thyroid disease ; ; PRIMARY OUTCOME: Thyroid I‐123 uptake. SECONDARY OUTCOME: thyroid function in terms of TSH, fT4 and T3 measurements. INCLUSION CRITERIA: . male . No mental illness . lnformed consent . Healthy, specifically no history of thyroid disease or renal insufficiency . Aged between 18‐50 years . Normal weight (BMl: '18.5‐25.0 kg/m2) . Maintained stable body weight for previous 6 months