Randomized, controlled, clinical trial for evaluation of the influence of platelet rich fibrin (PRF) in combination with bone substitute materials in use for regeneration of extraction sockets

INTERVENTION: Intervention 1: Pre‐molars ‐ Control 1: unfilled, untreated socket Intervention 2: Pre‐molars: High‐RCF‐PRF Intervention 3: Pre‐molars ‐ test group 1: socket preservation (type I extraction sockets) or ridge preservation (type II extraction sockets) with bone substitute material Intervention 4: Pre‐molars ‐ test group 2: socket preservation (type I extraction sockets) or ridge preservation (type II extraction sockets) with bone substitute material + low‐RCF‐PRF Intervention 5: Molars ‐ Control 1: unfilled, untreated socket Intervention 6: Molars ‐ High‐RCF‐PRF Intervention 7: Molars ‐ test group 1: socket preservation (type I extraction sockets) or ridge preservation (type II extraction sockets) with bone substitute material Intervention 8: Molars ‐ test group 2: socket preservation (type I extraction sockets) or ridge preservation (type II extraction sockets) with bone substitute material + low‐RCF‐PRF CONDITION: Bone‐ and soft tissue regeneration after tooth extraction K08.1 ‐ Loss of teeth due to accident, extraction or local periodontal disease PRIMARY OUTCOME: Bone gain in augmented region planned for implantation; [3 months post‐augmentation] SECONDARY OUTCOME: ‐ soft tissue healing (score 1‐4) [7 days post‐augmentation]; ‐ implant survival [up to 6 months post‐implantation]; ‐ bone change in augmented region [3 months post‐augmentation]; ‐ histological evaluation of vital bone, residual bone substitute material, connective tissue [3 months post‐augmentation]; ‐ overall soft tissue healing [7 days post‐surgery]; ‐ Oral Health Impact Profile questionnaire (OHIP‐14) [pre‐/post‐surgery]; ‐ peri implant soft tissue and bone tissue changes [up to 6 months post‐implantation]; ‐ further complications [up to 9 months post‐augmentation]; ‐ implant‐bone connection in follow‐up according to radiological evaluation [up to 6 months post‐implantation] INCLUSION CRITERIA: ‐ informed consent ‐ tooth/teeth in need of extraction ‐ patients planed for dental restoration via implantation ‐ indication for socket preservation / ridge preservation ‐ patients is suitable for two‐timed intervention ‐ patient will follow study‐related requirements and guidelines