The Role of the Amygdala–Anterior Cingulate Cortex–Prefrontal Cortex Circuit in Social Exclusion and Emotion Regulation Among Adolescents with Depressive Disorder and Nonsuicidal Self-Injury

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: NSSI + Health Education Group:Provide health education and standard care protocol;Non‐NSSI Group:Provide standard care protocol;NSSI + Mindfulness‐Based Intervention Group:Mindfulness‐based intervention added to standard care protocol; CONDITION: Major Depressive Disorder PRIMARY OUTCOME: Changes in NSSI Frequency at 4 Weeks Post‐Intervention Compared to Baseline; SECONDARY OUTCOME: Performance of Participants in the Emotional Face Go/No‐Go Task; INCLUSION CRITERIA: 1. Meets the diagnostic criteria for Major Depressive Disorder according to the DSM‐5; 2. PANSS positive symptom subscale total score <= 14; 3. HAMD‐17 score < 24; 4. Age between 10‐19 years old; 5. Normal reading, comprehension, and communication skills, can complete questionnaires and behavioral tests; 6. Voluntarily participates and signs the informed consent form. Subjects in the NSSI group must also meet the DSM‐5 criteria for NSSI; subjects in the non‐NSSI group must have never engaged in NSSI behavior.
Epistemonikos ID: 1eab00b1ebb701f30f3cadff853a6cd238ac0d8d
First added on: Oct 08, 2026