A randomized controlled trial to compare empiric antifungal therapy and D-index-guided early therapy during neutropenia. (CEDMIC trial)

INTERVENTION: D‐index‐guided early antifungal therapy Empiric antifungal therapy CONDITION: Hematological malignancies(acute leukemia, myelodysplastic syndrome, lymphoma, myeloma, and so on) PRIMARY OUTCOME: Proven/Probable invasive fungal infection INCLUSION CRITERIA: 1)Patients with hematological malignancies who undergo chemotherapy or stem cell transplantation 2)Aged between 16 and 79 years 3)Expected duration of neutropenia at least 7 days 4)No grade III‐IV renal or liver dysfunction 5)ECOG‐PS 0‐2 6)Written informed consent obtained