Research on the surgical model of integrated traditional Chinese and Western medicine for the full management of colorectal cancer - based on the distribution pattern of TCM syndrome types to study the effect of spleen-strengthening and detoxification methods on the adverse reactions of postoperative chemotherapy for colorectal cancer

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2024
INTERVENTION: chemotherapy alone group.:Use FOLFO Xor CapeO Xfirst‐line chemotherapy regimen, with at least 4 cycles of chemotherapy.;Spleen‐invigorating and detoxifying method combined with chemotherapy group.:On the basis of chemotherapy, the Yiqi, Jianpi and Anti‐Cancer Recipe (composed of: Radi XPseudostellariae, Poria Cocos, Atractylodes Rhizome, Tangerine Peel, Pinellia Pinellia, Shanzi Mushroom, Hedyotis diffusa, Scutellaria Barbata, Licorice) was taken orally at the same time. In addition, according to the researcher’s experience Make additions and subtractions of prescriptions: For severe qi deficiency, add Radi XPseudostellariae and Astragalus membranaceus; for severe nausea and vomiting, add Pinellia ternata, tangerine peel, and Inula; for qi stagnation and abdominal pain, add Corydalis chinensis, white peony root, costus, and Citrus aurantium; for those with mid‐coke deficiency and cold abdominal pain, Add dried ginger, Evodia, and cinnamon; for patients with palpitations and insomnia, add jujube kernels, Polygala, and Albizia Julibrissin bark; for patients with anorexia, add hawthorn, Divine Comedy, malt, etc., three times a day, 100ml each time; combined with chemotherapy for at least 4 cycles.; CONDITION: colorectal cancer. PRIMARY OUTCOME: Tongue;pulse;Clinical symptoms.;TCM syndrome types;Spleen deficiency symptom score.;KPS rating;Laboratory indicators (blood routine, liver and kidney function, tumor markers, immune function).;Piper fatigue score.;Toxicity and side effects indicators (blood system: white blood cells, red blood cells, hemoglobin, neutrophils, gastrointestinal reactions: oral ulcers, nausea and vomiting).; INCLUSION CRITERIA: Clinical observation of traditional Chinese medicine syndrome types in patients undergoing postoperative chemotherapy for colorectal cancer: ? Patients diagnosed pathologically as stage II‐IV colorectal cancer; ? Patients who have not undergone chemotherapy and no clear recurrence and metastasis at the time of enrollment; ? Ages =18 and =80 years old Adults within; ?KPS score =70 points (KPS score is the functional status scoring standard, the higher the score, the better the health status, and the more able to tolerate the side effects of treatment on the body); ?The patients are all post‐surgery cases. To clarify the effect of spleen‐strengthening and detoxification method on adverse reactions of postoperative chemotherapy for colorectal cancer: western medicine INCLUSION CRITERIA: ? Patients with pathologically diagnosed high‐risk stage II‐III colorectal cancer; ? No chemotherapy and no clear recurrence and metastasis at the time of enrollment; ? Adults aged =
Epistemonikos ID: 1e70d38dc48c6945ed6465d41f65685230a9f6c4
First added on: Apr 08, 2025