Systematic Evaluation of Effectiveness and Safety in the Treatment of Primary Dysenorrhea

Objective: Systematic evaluation of the effectiveness and safety of the treatment of primary dysmenorrhea (PD). Method: Comprehensive retrieval of the Chinese Biomedical Literature Database (CBM), CNKI, VIP Chinese Science and Technology Journal Database (VIP), Wanfang Data (WANFANG DATA), PubMed, Cochrane and others Zhongguan Clinical Research on Therapeutics of PD literature, selection of eligible literature for meta analysis. Results: Total 1,100 patients with PD were incorporated in 14 literature. Meta analysis showed total efficiency [RR=1.36,95% CI (1.24,1.49), Z=6.70, P^0.00001]; cure rate [RR=1.76,95% CI ( 1.35,2.28), Z=4.22, P^0.0001]; Visual Simulation Pain Scale Score [MD=-14.59,95% CI (-28.67, -0.51), Z=2.03, P=0.04]; Prostaglandin levels [MD=-2.77,95% CI (-14.57,9.03), Z=0.46, P= 0.65]; uterine hemodynamics, resistance index [MD=-0.15,95% CI (-0.20, -0.10), Z=5.97, P^0.00001], pacing index [MD=-0.69,95% CI (-0.74, -0.64), Z=25.79, P^0.00001], contraction period peak/diastolic period [ MD=-2.27,95% CI (-2.40, -2.14), Z=33.41, P≈ 0.00001], and the difference between the two groups was not statistically significant in the tolla group (including Western medicine, Chinese medicine, acupuncture). Conclusion: PD efficacy of tolla treatment is accurate and safe.