Study of the clinical effects by the central supply method of the acetic acid-free dialytic fluid

INTERVENTION: six months of Acetic acid component dialytic fluid use, and then 12 months of acetic acid‐free dialytic fluid use CONDITION: end‐stage renal failure PRIMARY OUTCOME: For a hemodialysis patient, we examine a 12‐month clinical response of acetic acid‐free dialytic fluid after use in acetic acid dialytic fluid for six months. Examination item are dialysis efficiency (Kt/V), a circulation change (mean blood pressure and the pulse), nourishment dialyzing are in a state (serum protein and albumin, nPCR), acidotic improvement effect (pH, HCO3‐, BE). SECONDARY OUTCOME: For a hemodialysis patient, we measure a 12‐month oxidation stress marker of acetic acid‐free dialytic fluid after use in acetic acid dialytic fluid for six months. Examination item are blood reduced glutathione/oxidized glutathione ratio and serum MDA‐LDL. INCLUSION CRITERIA: end‐stage renal failure patients with stable outpatient maintenance hemodialysis 20 years or older