Double Blinded, Randomized, Placebo-controlled Clinical Study for Nelumbinis Semen

Nelumbinis Semen, has been widely used as treatment of post‐menopause symptoms in women for hundreds of years in many Asian countries. This study examines whether PM011, standardized herbal medicine made from Nelumbinis Semen, treats stress in above 5 of BDI score of human subjects and discusses its potential as treatment for depressed patients. Subjects were divided into three groups, the placebo‐treated group (n = 10), the PM011‐2.4 g treated group (n = 11) and PM011‐4.8 g treated group (n = 11) per day. Alpha/Beta ratio of electroencephalogram (EGG), Beck Depression Inventory (BDI) and Stress Response Inventory (SRI) were conducted in order to measure changes in stress before and after 2 weeks of PM011 treatment.