Effects of high dose vitamin D supplementation on muscle mass and muscle strength in frail elderly people

INTERVENTION: Current information as of 13/07/10: Patients were randomised to receive either 1. 1800IU cholecalciferol (vitamin D3) daily 2. Placebo daily Medications were used for a period of six months. The end date for inclusion into this trial was December 2009. Initial information at time of registration Individuals are randomised to recieve either: 1. 1200 IU vitamin D/day and 1000 mg calcium/day 2. Placebo medications and 1000 mg calcium/day Medications will be used for a period of six months. CONDITION: Hypovitaminosis D on muscle mass and strength ; Musculoskeletal Diseases ; Frailty, increasing muscle mass PRIMARY OUTCOME: Differences in muscle strength (handgrip strength and quadriceps strength) between treatment and control group. SECONDARY OUTCOME: 1. Changes in mobility:; 1.1. Timed up and go test; 1.2. Walking distance; 2. Quality of life (using the health assessment questionnaire); 3. Falls INCLUSION CRITERIA: 1. Frail elderly people, aged greater than 65 years 2. Living in homes for the elderly 3. Serum vitamin D level less than 50 nmol/l Added 07/04/2011: 4: Stable health (including no history of recurrent falling or recent fracture).