A study to evaluate the exposure to selected smoke constituents in healthy smokers using B-003 for 5 days confined in a hospital

INTERVENTION: (Smokers) Use of subject's own brand for 2 days (confined in a hospital) Use of B‐003 for 5 days (confined in a hospital) (Smokers) Use of subject's own brand for 2 days (confined in a hospital) Continued use of of subject's own brand for 5 days (confined in a hospital) (Smokers) Use of subject's own brand for 2 days (confined in a hospital) Abstinence from smoking for 5 Days (confined in a hospital) CONDITION: Smokers PRIMARY OUTCOME: The difference of biomarkers of exposure to selected smoke constituents between the investigational tobacco products INCLUSION CRITERIA: Subjects who sign the study‐specific consent form Subjests who are confirmed to be in good health from all of the inspection results Smokers etc.