Effects of a single denosumab injection on reduction of total contact cast treatment and consolidation of bonefractures caused by acute Charcotfoot in patients with diabetes mellitus (CHARCOT study)

INTERVENTION: single denosumab injection 60mg vs placebo injection subcutaneous CONDITION: Diabetes Mellitus, Charcotfoot ; ; PRIMARY OUTCOME: Time to cession of total contact cast duration in combination with radiological improvement of bone quality between denosumab and placebo treatment SECONDARY OUTCOME: ‐ Prevention of footdeformation ( plantar pressure measurements i ; ; ‐ Changes in volume and foot temparature of both feet ‐ ; ; ‐ changes in clinical risk score ; ; ‐ changes in plasma markers of bone metabolism INCLUSION CRITERIA: ‐Radiologically proven Charcot foot (x ray,CT or MRI) ‐ Male/female gender ‐ Confirmed diagnosis of either type 1 or type 2 diabetes with neuropathy