Gui Shen Yi Jing Granules for Diminished Ovarian Reserve with Kidney Deficiency Syndrome: A Randomized Controlled Trial

INTERVENTION: experimental group:Gui Shen Yi Jing Granules plus Coenzyme Q10 placebo;control group:Coenzyme Q10 plus Gui Shen Yi Jing Granules placebo; CONDITION: Diminished Ovarian Reserve PRIMARY OUTCOME: Basal serum Follicle‐Stimulating Hormone; SECONDARY OUTCOME: Basal serum luteinizing hormone;Follicle‐Stimulating Hormone/Luteinizing Hormone;estradiol;anti‐Müllerian hormone;Basal antral follicle count;Scoring of Traditional Chinese Medicine Syndromes;Modified Kupperman score; INCLUSION CRITERIA: (1) fulfillment of the diagnostic criteria for diminished ovarian reserve; (2) fulfillment of the Traditional Chinese Medicine pattern differentiation criteria for kidney deficiency syndrome; (3) age between 25 and 45 years (25 = age < 45); (4) baseline follicle‐stimulating hormone level between 10 and 25 IU/L (10 IU/L = baseline FSH < 25 IU/L); and (5) voluntary provision of written informed consent after being fully informed of the study details.