Effect of Curcumin associated with LED application in the treatment of residual pockets of patients with Chronic Periodontitis and type 2 Diabetes Mellitus

INTERVENTION: D02.455.326.146.485.222.222 E02.186.500 E06.721.189.350 Procedure/surgery This is a split‐mouth desing study in which twenty‐five diabetics with chronic periodontitis on supportive periodontal therapy were selected (HbA1c bigger or equal to 6, 5%). In each patient, all residual pockets in each quadrant with probing depth (PD) bigger or equal to 5 mm were randomly allocated in a split‐mouth study to receive: (1) scaling and root planing (SRP) in a single session and irrigation with saline solution (SRP Group); (2) SRP in single session and irrigation with Curcumin 100 mg/ml solution (CUR Group); (3) SRP in single session, irrigation with saline solution and irradiation with LED (LED group); (4) SRP in single session, irrigation with CUR solution, followed by LED irradiation (aPDT Group). The antimicrobial photodynamic therapy (aPDT) was performed using CUR (100 mg / ml) followed by LED irradiation (InGaN, 465‐485 nm, 100 mW/cm2, 60 seconds) after SRP treatment at all sites with probing depth bigger or equal to 5mm. Clinical examinations will be performed at baseline, at 90 and 180 days after treatment. CONDITION: C07.465.714.533.324 C18.452.394.750.149 Chronic Periodontitis, Diabetes Mellitus ; C07.465.714.533.324 ; C18.452.394.750.149 PRIMARY OUTCOME: The primary outcome of the study will be the mean of changes in the level of clinical attachment in moderate and deep pockets.; ; SECONDARY OUTCOME: Clinical evaluation of visible plaque index, bleeding on probing, gingival recession and probing depth after 90 and 180 days of periodontal treatment. INCLUSION CRITERIA: Patients with age equal to or greater than 30 years and less or equal than 70 years (MATARAZZO et al., 2008); diagnosis of chronic periodontitis that have undergone periodontal treatment in a period of 3 to 6 months, with at least 4 sites with probing depth (PD) bigger or equal than 5 mm and loss of clinical attachment (CAL) bigger or equal than 3 mm with bleeding on probing (BOP) (APP, 2015); patients diagnosed with type 2 diabetes mellitus (HbA1c equal to or greater than 6.5%) (SACKS et al., 2011); present at least 15 teeth, excluding third molars (ASSEM, 2015); at least 1 site with PD equal to or greater than 5 mm (residual pocket with bleeding on probing) per quadrant.