Study on the Psychological Intervention Efficacy and Mechanism of TCM Cognitive-Behavioral Emotional Regulation in Patients with Amyotrophic Lateral Sclerosis Based on the Gut-Brain Axis and Intestinal Microbiota

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Control group (routine mental health education group):Standard mental health education includes information on diseases, emotional support, and guidance on daily care; each session lasts at least 30 minutes and is conducted twice a week.;Experimental group (TCM cognitive‐behavioral emotional regulation group):Traditional Chinese medicine’s cognitive‐behavioral approach to regulating emotions involves a cognitive reconstruction phase: by applying the principles of traditional Chinese medicine related to emotions, correcting cognitive patterns, and using music to improve psychological state, this approach helps patients identify and modify catastrophic thinking and negative automatic thoughts, thereby fostering a more balanced perspective on the progression of the disease, remaining functional abilities, and the meaning of life. The behavioral training phase entails exercises such as qigong movements, breathing techniques, and physical activities, supplemented by music, in order to enhance patients’ emotional stability, sense of self‐efficacy, and control over their physical condition, thus facilitating psychological adaptation and the re‐establishment of a normal lifestyle.; CONDITION: Amyotrophic Lateral Sclerosis PRIMARY OUTCOME: Anxiety symptoms;Psychological resilience;Depressive symptoms; SECONDARY OUTCOME: Secondary psychological outcome indicators;Respiratory function score;Revised ALS Functional Rating Scale;Pulmonary function parameters (FVC, FEV1, VC, etc.); INCLUSION CRITERIA: 1.Patients with ALS diagnosed in accordance with the Gold Coast Criteria; 2.Patients aged >= 18 years; 3.In stable disease stage or clinical remission stage; 4.Possess intact basic cognitive function and be capable of understanding scale contents and completing assessments; 5.Meet the TCM diagnostic and syndrome differentiation criteria; 6.Conform to TCM diagnostic and syndrome typing criteria;
Epistemonikos ID: 1c81b3d79b19a49a4a094ccc8a6db78512f35827
First added on: Oct 08, 2026