Treatment of acne vulgaris with topically applied erythromycin and tretinoin.

Authors
Category Primary study
JournalActa dermato-venereologica
Year 1978
A twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. Therapeutic enhancement by this combination can be attributed to the different modes of action, erythromycin acting chiefly by suppressing Propionibacterium acnes, while tretinoin is comedolytic. In addition, by altering the horny layer barrier, tretinoin doubtless increases the penetration of erythromycin.
Epistemonikos ID: 1ba48a719d4e1568836ec6cfa1f70411f51ad724
First added on: Sep 10, 2023