The effect of Ginseng augmentation on the intensity of opioid withdrawal symptoms

INTERVENTION: drug group: patients recieved 250 mg oral capsule of ginseng twice daily for 15 days along with MMT protocol. Intervention 1: drug group: patients recieved 250 mg oral capsule of ginseng twice daily for 15 days along with MMT protocol. Intervention 2: placebo group: patients recieved placebo oral capsule of gensing twice daily for 15 days along with MMT protocol. Placebo placebo group: patients recieved placebo oral capsule of gensing twice daily for 15 days along with MMT protocol. Treatment ‐ Drugs CONDITION: Mental and behavioural disorders due to use of opioids / Dependence syndrome opioid withdrawal. ; Mental and behavioural disorders due to use of opioids / Dependence syndrome PRIMARY OUTCOME: Clinical opioid withdrawal symptoms. Timepoint: days 0,1,7,10,15. Method of measurement: clinical opioid withdrawal scale. SECONDARY OUTCOME: Methadone dosage. Timepoint: every day. Method of measurement: base on ducuments and patients records. INCLUSION CRITERIA: IINCLUSION CRITERIA: ‐all patients were male abusing opioids for at least 1 year ‐age range was between 18 and 50. ‐all patients were at the beginning of induction phase of MMT protocol ‐subjects should not recieve any other medication which affects withdrawal symptoms. Exclusion criteria: ‐incidence of any allergic effect to ginseng or other ingredients of capsules ‐patient unlikely to continue the intervention ‐positive urine tests indicating abuse of any opioid or stimulant drug ‐missing more than 1 dose of ginseng or a day of methadone treatment