Study on the brain network mechanism of transcutaneous auricular vagus nerve stimulation in the treatment of ulcerative colitis based on functional magnetic resonance imaging

INTERVENTION: healthy control group:none;control group:transcutaneous auricular vagus nerve stimulation;Test team:transcutaneous auricular vagus nerve stimulation; CONDITION: Ulcerative colitis PRIMARY OUTCOME: Concentration of fecal calcium sanitrin;Mayo defecation count rating;Mayo bloody stool score;heart rate variability;Brain function magnetic resonance data acquisition;Serum inflammatory cytokines; INCLUSION CRITERIA: Patients who meet the following si Xitems must also be included in this study: (1) There are colonoscopy and pathological diagnosis reports of tertiary hospitals that meet the diagnostic criteria for ulcerative colitis; (2) The lesions range from rectum (E1) or left colon (E2) or total colon type (E3); (3) Mayo defecation score or bloody stool score of 1 or 2 points, and the disease activity is mild and moderate; (4) Those between the ages of 18 and 70; (5) Subjects should only take mesalazine before entering the group; (6) Voluntary examination and I will sign the informed consent form. Criteria for the diagnosis of Ulcerative Colitis: According to ACG Clinical Guideline: Ulcerative Colitis in Adults, the diagnosis should be made based on the exclusion of infectious and non‐infectious Colitis by comprehensive analysis of Clinical manifestations, endoscopy, and histopathology.