Accelerated Repetitive Transcranial Magnetic Stimulation for Adolescent Anhedonic Depression

INTERVENTION: Experimental group:Accelerated Repetitive Transcranial Magnetic Stimulation Combined with Fluoxetine;Control group:sham Stimulation Combined with Fluoxetine; CONDITION: depression PRIMARY OUTCOME: Hamilton Depression Scale‐24;Chinese Version of the Anhedonia Scale for Adolescents; SECONDARY OUTCOME: Wisconsin Card Sorting Test;IL‐1ß;IL‐6;TNF‐a; INCLUSION CRITERIA: 1. Aged from 13 to 18 years, Han ethnicity. 2. Diagnosed with major depressive disorder according to the Structured Clinical Interview for the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (SCID‐5), consistent with DSM‐5 diagnostic criteria. 3. Baseline total score of the Chinese version of Adolescent Anhedonia Scale (ASA‐C) >= 21 points; a total score greater than 21 points was defined as significant anhedonia. 4. Baseline total score of the 24‐item Hamilton Depression Rating Scale (HAMD‐24) >= 20 points. 5. No antidepressant medication used within 3 months before enrollment. For participants with previous medication history, a washout period of at least five drug half‐lives was required. 6. Able to complete the whole course of intervention and follow‐up, and cooperate with scale evaluation and peripheral blood collection.