Progression of Striatal and Extrastriatal Degeneration in PD and PSP Patients

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2015
This longitudinal study aims to research cognitive and gait phenotypes of Parkinson\'s disease and Supranuclear Palsy as well as to provide markers to track diseases progression using a multi-modality approach based on 3D-gait analysis and MR Imaging. Specifically, this study want to identify cognitive pattern and gait-related cerebral diffusion/functional connectivity in PD and PSP patients and to verify their progression over a period of 18 months. In summary, the current protocol proposed to investigate the following issues: * to perform a multifactorial quantitative analysis of outcomes for PD and PSP compared to a control group in order to categorize cognitive and gait pattern in the group of patients and verify if the gait can be useful as discriminator for diagnosis. * to analyze whether diffusion and resting-state functional connectivity indices are correlated with clinical disease severity scores and motor scores and how they change over time (18 months later).
Epistemonikos ID: 1a1b0e543ce4f9295c1cad9d0c4309cfee50047c
First added on: May 22, 2024