Homeopathy for Depression: a randomized, four-armed, partial double-blind study.

INTERVENTION: Trade Name: V (individualized homeopathic Q‐Potencies registered under ATC‐Code V60A ) Pharmaceutical Form: Oral drops, solution Pharmaceutical form of the placebo: Oral drops, solution Route of administration of the placebo: Oral use CONDITION: F32.1 Moderate Depressive Episode PRIMARY OUTCOME: Main Objective: To assess the specific effect of an individualized homeopathic treatment with Q‐potencies as compared to placebo for Major Depression (moderate depressive episode).; ; To assess the specific effect of a complete homeopathic patient history as compared to a rather conventional patient history.; ; Primary end point(s): mean HAM‐D total score after 6 weeks Secondary Objective: Effect of homeopathic medicines after 2 and 4 weeks compared to placebo, and effect of a complete homeopathic patient history compared to a rather conventional patient history. ; ; Safety evaluation; ; Effect of homeopathic medicines and placebo using patient history/case analysis Type 1 (complete homeopathic patient history plus homeopathic questionnaire) compared to the effect of homeopathic medicines and placebo using patient history/case analysis Type 2 (rather conventional patient history plus homeopathic questionnaire) (interaction); INCLUSION CRITERIA: Male and female patients between 18 and 65 years Major Depression diagnose made by a psychiatrist Willingness to comply with study procedures Patients not using antidepressants or anxiolytic drugs (exception Lorazepam, maximal dose 1.5 mg/day as rescue medication) Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range