The effects of multivitamin supplementation on memory and brain function in elderly women experiencing memory decline.

INTERVENTION: Swisse Women's Ulitivite 50+ V One tablet per day for 16 weeks. RETINYL ACETATE (equiv. to 2500 IU of vitamin A) 862.5 mcg d‐ALPHA‐TOCOPHERYL ACID SUCCINATE (equiv. vitamin E 24.2 IU) 20 mg THIAMINE HYDROCHLORIDE (vitamin B1) 30 mg RIBOFLAVINE (vitamin B2) 30 mg NICOTINAMIDE (vitamin B3) 20 mg CALCIUM PANTOTHENATE (vitamin B5) (equiv. pantothenic acid 64.13mg) 70 mg PYRIDOXINE HYDROCHLORIDE (vitamin B6) (equiv. pyridoxine 24.68mg) 30 mg CYANOCOBALAMIN (vitamin B12) 115 mcg CHOLECALCIFEROL (vitamin D3) (equiv. vitamin D 200 IU) 5mcg BIOTIN (vitamin H) 150 mcg FOLIC ACID 500 mcg CALCIUM ASCORBATE DIHYDRATE (vitamin C)(equiv. ascorbic acid 165.3mg) 200 mg PHYTOMENADIONE (vitamin K1) 60 mcg CITRUS BIOFLAVONOIDS EXTRACT 20 mg CALCIUM OROTATE (equiv. calcium 10mg) 100 mg MAGNESIUM ASPARTATE DIHYDRATE (equiv. magnesium 6.74mg) 100 mg SELENOMETHIONINE (equiv. selenium 26mcg) 65 mcg MOLYBDENUM TRIOXIDE (equiv. molybdenum 45mcg) 67.5 mcg CHROMIUM PICOLINATE (equiv. chromium 50 mcg) 402 mcg MANGANESE AMINO ACID CHELATE (equiv. manganese 3mg) 30 mg FERROUS FUMERATE (equiv. iron 5mg) 16.01 mg COPPER GLUCONATE (equiv. copper 1.2mg) 8.57 mg POTASSIUM IODIDE (equiv. iodine 149.83mcg) (equiv. potassium 46.18mcg) 196 mcg ZINC AMINO ACID CHELATE (equiv. zinc 15mg) 75 mg Lactobacillius rhamnosus 80 million organisms Lactobacillus acidophilus 80 million organisms Bifidobacterium longum 35 million organisms VACCINIUM MACROCARPON FRUIT DRY (patented cranberry PACRAN) 800 mg SILYBUM MARIANUM DRY FRUIT (St. Mary’s thistle) (equiv. flavanolignans calculated as silybin 17.14mg) 1500 mg GINKGO BILOBA LEAF DRY (Maidenhair tree) (equiv. Ginkgo flavonglycosides 4.8mg and ginkgolides and bilobalide 1.2mg) 1000 mg TUNERA DIFFUSA LEAF DRY (Damiana) 500 mg SCUTELLARIA LATERIFLORA HERB DRY (Skullcap) 50 mg VITIS VINIFERA DRY SEED (Grape seed) (equiv. procyanidins 7.9mg) 1000 mg URTICA DIOICA LEAF DRY (Nettle) 100 mg UBIDECARENONE (Co‐enzyme Q10) (from patented Ultrasome CoQ10) 2 mg CYNARA SCOLYMUS LEAF DRY (Globe artichoke) 50 mg CIMICIFUGA RACEMOSA ROOT & RHIZOME DRY (Black cohosh) 200 mg CURCUMA LONGA RHIZOME DRY (Tumeric) 100 mg WITHANIA SOMNIFERA ROOT DRY (Ashwagandha) 500 mg CRATAEGUS MONOGYNA FRUIT DRY (Hawthorn) 100 mg SILICA COLLOIDAL ANHYDROUS (equiv. silicon 9.35mg) 20 mg BACOPA MONNIERI WHOLE PLANT DRY (Bacopa) (equiv. bacosides calculated as bacoside A 1.125mg) 50 mg LECITHIN POWDER – SOY PHOSPHATIDYLSERINE ENRICHED SOY (equiv. phosphatidylserine 2mg) 10 mg SPEARMINT OIL 2 mg VACCINIUM MYRTILLUS FRUIT DRY (Bilberry) (equiv. anthocyanosides 324mcg) 100 mg TAGETES ERECTA FLOWER DRY (Marigold) (Lutein esters calculated as lutein (of Tagetes erecta) 1mg) 100 mg CONDITION: Blood markers of antioxidant status and general health Brain function Cardiovascular function Cognitive and memory performance Memory decline PRIMARY OUTCOME: Patterns of brain activity during memory activation tasks using the steady state visually evoked potential (SSVEP) methodology. Performance on a computerised cognitive task battery. memory performance on standard neuropsychological tasks. INCLUSION CRITERIA: Females aged 65‐ 80 years who are experiencing memory decline. SECONDARY OUTCOME: Blood pressure and augmentation index as measured by the Sphygmocor pulse wave analysis system Levels of homocysteine; c‐reactive protein; fibrinogen; lipids; vitamins B6, B12, C, E and folate; and protein carbonyls in the blood.