Effect of Transcutaneous Auricular Vagus Nerve Stimulation on the Incidence of Postoperative Delirium in Elderly Patients with Diabetes Undergoing Orthopedic Surgery

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Group:Transcutaneous Auricular Vagus Nerve Stimulation (taVNS);Sham Stimulation Group:Sham Stimulation; CONDITION: Postoperative delirium (POD) PRIMARY OUTCOME: Postoperative Delirium (POD); SECONDARY OUTCOME: Inflammatory Stress Markers;Sleep Quality;Postoperative Pain and Adverse Events;Perioperative Glycemic Control;Anxiety and depression (HADS); INCLUSION CRITERIA: 1. Age = 65 years, meeting the definition of elderly patients; 2. Previously diagnosed with type 2 diabetes, with blood glucose basically under stable control; 3. Planned to undergo elective orthopedic surgery under general anesthesia (such as hip replacement, fracture internal fixation, etc., with an expected surgery duration of 1‐5 hours); 4. Meets the PACU admission criteria postoperatively; 5. Patient and family are informed and have signed the informed consent form.
Epistemonikos ID: 19ac9837992faabd8ce5785f1f63916486354f7a
First added on: Jul 25, 2026