Probiotic supplementation with Lactiplantibacillus plantarum OL3246 and quality of life of patients with Parkinson's disease

INTERVENTION: Permuted‐block randomization with a fixed block size of four (2:2 ratio) was generated using a computer algorithm. Both participants and researchers were blinded to the group allocation. 1. Intervention group: capsules, containing Lactiplantibacillus plantarum OL3246 (deposit number: KPD 1760) lyophilizate and excipients (1.4 × 10^10 CFU per day; taken orally as a 370 mg capsule containing 7 × 10^9 CFU/capsule twice a day: morning and evening). 2. Placebo group: Placebo capsules contained an equal mass of fulfillment, while the probiotic was substituted by maltodextrin (taken orally as a 370 mg capsule twice a day: morning and evening). The duration of the intervention is 3 months. CONDITION: Evaluating supplementation effect on quality of life in patients with Parkinson's disease. ; Nutritional, Metabolic, Endocrine PRIMARY OUTCOME: Quality of life measured using the Parkinson's Disease Questionnaire (PDQ‐39) at pre ‐ baseline (timepoint 0), post ‐ after 3 months INCLUSION CRITERIA: 1. Diagnosed Parkinson's disease according to UK PDS BB 2. Overall good health condition 3. MMSE > 24