Perioperative steroids administration in hepatectomy: a prospective randomized study

INTERVENTION: The patients were assigned randomly to a control group or a steroid group in which patients received 500mg of hydrocortizon just before hepatic pedicle clamping, 300mg on postoperative day (POD) 1, 200mg on day2 and 100mg on day3. administration only saline solution CONDITION: The patients who were planned to hepatic resection in the Department of Digestive Surgery at Nihon University Itabashi Hospital, Tokyo, Japan. PRIMARY OUTCOME: The primary endpoint was serum level of total bilirubin (T.bil) on POD2. SECONDARY OUTCOME: The other serum levels related to liver function, inflammatory cytokine levels, and postoperative complications were also compared between the two groups. INCLUSION CRITERIA: Eligibility criteria included from 15 to 84 years patients who were planned to hepatic resection and had adequate functional reserve of the heart, lungs, and kidneys. Patients were excluded who if they had already treated with taken steroids, had unstable condition of gastric ulcer or past history of acute myocardial infarction. Randomization stratified by Child‐Pugh class (A or B)