中西医结合治疗新型冠状病毒肺炎37例临床研究 / Clinical Study on 37 Case of COVID-19 Treated with Integrated Traditional Chinese and Western Medicine

ABSTRACT: OBJECTIVE: To investigate COVID-19 and its related T cell expression in the treatment of Toujie Quwen granules and Arbidol. METHODS: Seventy three COVID-19 patients were collected and divided into 2 groups:the treatment group(n=37)and the control group(n=36). The control group was given oral medicine of Arbidol,and the treatment group was given Toujie Quwen granules and Arbidol. The TCM syndrome scores, peripheral blood WBC cell counts,LYM cell counts,LYM ratio,CRP,CD4~+,CD8~+,CD4~+/CD8~+and CD45~+were compared before and after treatments. RESULTS: After treatment, the TCM syndrome score of the treatment group was significantly reduced, the absolute value of lymphocyte was up-regulated, CRP was down regulated, the differences were statistically significant (P < 0.05,P < 0.05). Compared with the control group,the increase of LYM and decrease of CRP in the treatment group were better(P < 0.05,P < 0.05);there was no significant difference in WBC count and LYM ratio(P > 0.05). In the early stage,CD4~+in the control group decreased after a earlier up-regulation,and the expression of CD8~+and CD45~+in the treatment group was stable after up-regulation; there was no significant difference between the two groups(P > 0.05). CD4~+/CD8~+increased in the treatment group and decreased in the control group(P < 0.05). CONCLUSION: Symptoms of COVID-19 patients could be alleviated by early and timely application of the combined solution of Toujie Quwen granules and Arbidol. The expression of T cell counts can be controlled and the immune function can be restored.