The Effect of Acupressure on Severity of Fatigue and Pain of Multiple Sclerosis (MS) disease in female members of MS Association

INTERVENTION: Control group: same the intervention group rather than just do the palpation. Intervention 1: Patients in the intervention group or individual instruction for acupressure points (LI4, SP6, ST36) for two minutes on each side, three times a day for two weeks. Intervention 2: Control group: same the intervention group rather than just do the palpation. Patients in the intervention group or individual instruction for acupressure points (LI4, SP6, ST36) for two minutes on each side, three times a day for two weeks Treatment ‐ Other CONDITION: multiple sclerosis multiple sclerosis. ; multiple sclerosis PRIMARY OUTCOME: Fatigue reduction. Timepoint: Before the intervention, immediately after, two weeks after the first two weeks after the last intervention. Method of measurement: Fatigue Severity Scale. Pain reduction. Timepoint: Before the intervention, immediately after, two weeks after the first two weeks after the last intervention. Method of measurement: Visual analog scale. SECONDARY OUTCOME: Severity of fatigue. Timepoint: Before the intervention, immediately after, two weeks after the intervention and four weeks after the first intervention. Method of measurement: Fatigue Severity Scale. Severity of pain. Timepoint: Before the intervention, immediately after, two weeks after the intervention and four weeks after the first intervention. Method of measurement: Visual analog scale. INCLUSION CRITERIA: INCLUSION CRITERIA: women with stable vital signs; lack of wounds and deformity in the LI4( When the thumb is in full extension, the middle point of the angle between the first and second metacarpal), ST36(The width of a finger tip to the side with the lower edge of the tibia 3 cun below the knee), SP6(or sanyingiao 3 cun above the inner ankle to the back edge of the posterior tibia); being able to read and write; confirmed fatigue related to MS; no history of using acupressure; no history of smoking, using drugs or pills; age between18‐40 and EDSS is between 0‐5.5. Exclusion criteria: unwillingness to continue participation in the trial; complications during the procedure; known physical and mental disorders; being perform the acupressure point 4LI, ST36, SP6 and don't have any sense of warmth, heaviness, swelling or numbness and not performing more than a quarter of days.