A comparison of various antioxidant preparations on insulin sensitivity in Type 2 diabetes patients

INTERVENTION: Intervention1: Omega‐3 Fatty acids: Capsule omega 3 fatty acids 120 mg EPA + 180 mg DHA single dose H.S Intervention2: &#945; ? lipoic acid + Methyl cobalamine: Capsule of &#945;‐ lipoic acid (100 mg B.D) + methyl cobalamine 500mcg O.D Intervention3: Methyl cobalamine: methyl cobalamine 500mcg O.D Intervention4: vitaminE: Capsules of vit E 200 mg per day O.D Intervention5: Placebo: Capsules of Placebo Control Intervention1: placebo: CONDITION: Type 2 Diabetes Mellitus PRIMARY OUTCOME: insulin sensitivity by HOMA and QUICKI‐‐‐‐‐‐Timepoint: At start of study and at end of study SECONDARY OUTCOME: Blood Glucose levels‐‐‐‐‐‐Timepoint: At start of study and every 15 days thereafter Body mass index ( B.M.I)‐‐‐‐‐‐Timepoint: At Start Of Study And At End Of Study Serum lipid levels‐‐‐‐‐‐Timepoint: At Start Of Study And At End Of Study Serum Malodialdehyde (MDA) levels‐‐‐‐‐‐Timepoint: At Start Of Study And At End Of Study serun glycosylated haemoglobin‐‐‐‐‐‐Timepoint: At Start Of Study And At End Of Study INCLUSION CRITERIA: This study will enrol patients both men and women with age between 21‐60 years of known cases of type 2 diabetes mellitus, attending medicine or diabetic O.P.D of SGH Pune and having the following parameters ‐indicative of decreased insulin sensitivity:‐ Any of the below two criteria: 1)B.M.I > 27 kg/m2 ‐ < 40 kg/m2 17 2)Waist circumference of > 102 cm in men or > 88 cm in women 3)High‐density lipoprotein cholesterol (HDL‐C) level of < 40 mg/dL in men or < 50 mg/dL in women/ Fasting triglyceride level of 150 mg/dL or higher