Reduced frequency of migraine attacks following COVID-19 disease

Background: SARS-CoV-2 is a virus affecting different organs and causing a wide variety and severity of symptoms. Headache as well as loss of smell and taste are the most frequently reported neurological manifestations of SARS-CoV-2 induced coronavirus disease 19 (COVID-19). Case Presentation: Here we report on a 57-year old male patient with chronic migraine and medication overuse headache who fell ill with COVID-19. For many years prior to his Sars-Cov2 infection he suffered from very frequent migraine attacks and for control of headache he had been taking triptans almost daily. In the 16-month period before outbreak of COVID-19 on 98% of the days triptans were taken with only a 21-day prednisolone-supported triptan holiday, which, however, had no longer-lasting consequences on migraine frequency. Upon Sars-Cov2 infection, the patient developed only mild symptoms including fever, fatigue and headache. Directly following recovery from COVID-19 the patient surprisingly experienced a period with largely reduced frequency and severity of migraine attacks. Indeed, during 80 days following COVID-19, migraine as well as triptan usage were restricted to only 25% of the days no more fulfilling criteria of chronic migraine and medication overuse headache. Conclusion: SARS-CoV-2 infection might be capable of triggering mitigation of migraine.