Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity

This randomized crossover clinical trial aims to evaluate the effect of a synbioticcontaining Lactobacillus acidophilus and inulin on cognitive function in adults withobesity and mild cognitive impairment. Forty participants aged 30‐40 years will berandomly assigned to two groups. Participants will receive either the synbioticintervention or a control preparation, followed by crossover to the alternateintervention. Cognitive function will be evaluated using the Montreal CognitiveAssessment (MoCA), Mini‐Mental State Examination (MMSE), and Memory Alteration Test(M@T). Fecal butyrate and Lactobacillus acidophilus, as well as serum inflammatorycytokines and BDNF, will also be assessed to explore potential mechanisms involving thegut‐brain axis.