Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women

INTERVENTION: Clinical randomized controlled trial, double‐blind, 3 arms. Women between 18 and 49 years will be voluntarily recruited from the local community. Each volunteer you be submitted to general physical exams, including: medical history, rest and exercise electrocardiogram, blood pressure measure before the beginning of the resistance training program. After completing the clinical exams for inclusion, will be selected 60 pre��menopausal sedentary women. They will be randomly divided into three groups of 20. Group 1 ‐ will perform weekly undulating periodization of resistance training, group will perform daily undulating periodization, and control group. Initially, will be analyzed: 1)Maximal strength evaluations ‐ after two weeks of adaptation to resistance exercises and clinical evaluation maximal strength (1RM) tests will be performed; 2) Resistance training ‐ will be performed with weekly and daily undulating periodization models. En the daily undulating model, training intensity will be increased in each day of the week, for example, day 1 8‐10RM (repetitions maximum) day 2 3‐6RM and day 3 12‐15RM load, while for the weekly undulating the intensity adjustment will occur weekly, week 1 of 8‐10RM, week 2 of 3‐6RM and week 3 of 12‐15RM; 3) Anthropometry; 4)Body composition ‐ body composition analysis of the volunteers, before and after the training period will be done by the Dual‐energy X‐ray absorptiometry; 5)Blood pressure ‐ the measure of systolic (SBP) and diastolic blood pressure (DBP), in weeks 0, 12 and 24 will be done by the auscultatory method; 6) Cytokines measure ‐ plasma cytokines and resistin, and salivary immunoglobulin A ‐ saliva drawn will be performed to remove cells from the oral mucosa. Then, swabs tips will be separated with scissors and transferred to 1,5 ml to measure immunoglobulin A in saliva. Blood samples (3ml) will be collected from the antecubital vein with vaccumtainer tubes before, immediately after, 24h and 48h after the first resistance E02.779.483.875 CONDITION: C14.907.489 Women with different genotypes of polymorphism of the Angiotensin Converting Enzyme (ACE) ; C14.907.489 PRIMARY OUTCOME: Improvement of the metabolic profile measured by blood cytokines, lipidogram, insulin and glucose SECONDARY OUTCOME: Decrease of the cardiovascular risk factors, also measured by blood pressure parameters after six months INCLUSION CRITERIA: To be pre‐menopausal aged between 18‐49 years and no regular practice of exercise in the previous 12 months