Stabilization of DNA double and triple helices by conjugation of minor groove binders to oligonucleotides.

Category Primary study
JournalNucleosides, nucleotides & nucleic acids
Year 2003
New conjugates containing two parallel or antiparallel carboxamide minor groove binders (MGB) attached to the same terminal phosphate of one oligonucleotide strand were synthesized. The conjugates interact with their target DNA stronger than the individual components. Effect of conjugated MGB on DNA duplex and triplex stability and their sequence specificity was demonstrated on the short oligonucleotide duplexes and on the triplex formed by model 16-mer oligonucleotide with HIV polypurine tract.
Epistemonikos ID: 15e068c550edc091049eaf5232975132e7293793
First added on: Dec 07, 2021